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Figure 5

Accepted: Published: Version of record: Issue date: DOI:

Compounds such as resveratrol, curcumin, quercetin, EGCG, berberine, baicalein, polydatin, and phlorizin activate AMPK-SIRT1/PGC-1 and PI3K-Akt pathways, enhance mitochondrial biogenesis and bioenergetics, suppress NF-B/NLRP3 driven neuroinflammation, reduce ROS production, and improve insulin responsiveness

The xCT inhibitor, sulfamezosin (SAS), has certain effects on paclitaxel-resistant efficacy in the uterine serous cancer cell system, and its damage to paclitaxel-resistant cells is greater than in other sensitive cells, therefore, it induces ferroptosis rather than apoptosis (74)

In addition, it mirrors the pattern of cell death that seen in humans, with a greater impact on the SN pars compacta compared to the ventral tegmental area (German et al